David McK. Bird

William Neal Reynolds Distinguished Professor

Department of Plant Pathology and Bioinformatics Research Center

BRC office: Ricks Hall 1, Lampe Drive, Raleigh NC 27695. Currently closed for renovation.
Research lab: Suite 1400, Partners II, 840 Main Campus Drive, Raleigh NC 27606
Tel: (919) 515-1967 Fax: (919) 515-9500

Dr. Julian R. E. Wells (deceased): Ph. D.

Dr. Donald L. Riddle: postdoc.


David Bird was born in the “Riverland” wine district of Australia in 1958. He attended the University of Adelaide, and in 1984 received a Ph.D. in Biochemistry. He then spent three years researching C. elegans developmental genetics with Don Riddle in Columbia, MissouriFollowing that training, David joined the faculty of the University of California-Riverside, and in 1995 moved to NC State University to join the faculty in Plant Pathology. Dr. Bird sits on numerous university and professional panels and committees, including having served as Chair of the University Research Committee, as Editor-in-Chief of the Journal of Nematology, and as a member of the Science Advisory Board of Divergence Inc. He is Associate Director of the NCSU Bioinformatics Research Center (Interim-Director, 2011-13). Since 2006, Bird has been Director of the university’s Genomic Sciences Graduate Program. In 1996, Bird was named the Stoll-Stunkard Memorial Lecturer by the American Society of Parasitologists, and in 2012, Dr. Bird was named William Neal Reynolds Distinguished Professor. In 2013, Dr. Bird was elected Fellow of The Society of Nematologists.


Dr. Bird's research interests include: nematode biology and development; genome organization and evolution; structure-function relationships; host-parasite interactions; evolution of parasitism; host responses and resistance/susceptibility to pathogens; plant development.

The primary focus of his research group is to understand the mechanisms underlying parasitic interactions between nematodes and plants. David was a pioneer in framing the key questions in the context of nematode and host development. Together with collaborators world-wide, his group has been instrumental in establishing the root-knot nematode, Meloidogyne hapla, as the preeminent genetic system to model less-tractable nematode-host interactions, and as a platform for comparative genomics (www.hapla.org). His current program also emphasizes vaccine development for malaria-like diseases of cats and dogs.


In addition to administrative duties as the Director of the interdisciplinary/interdepartmental Genomic Sciences Graduate Program, Dr. Bird teaches in three classes: PP501, PP610/810, and PP790.

PP 610/810-006/Special Topics:  1 credit, Fall 2012


PP 790-006/Special Topics: Advances in Host-Microbe Interactions. 3 credits, Fall 2012 (http://statgen.ncsu.edu/pp790/)

Comprised of 3 five-week modules, this course will provide students with a high-level literature driven overview of recent advances in our understanding of microbial signaling events as they relate to parasitism, mutualism, and host responses. The intent of the course is to promote critical thinking, conceptual learning, and professional development in contemporary biological science. The course will consist of lectures and discussions (MWF) led by the instructors as well as active student involvement that will include leading discussions of published literature. Students with interests in host and pathogen biology, genomic sciences, cellular signaling, and molecular genetics are encouraged to enroll. 

Dr. Bird teaches Module I: “Changing ideas in plant-microbe interactions: A funding approach".

Selected Publications: 

Five Most Recent Publications

DM Bird, JT Jones, CH Opperman, T Kikuchi, EGJ Danchin. 2013. Signatures of adaptation to plant parasitism in nematode genomes. Parasitology, in press.

BG Bobay, PM DiGennaro, EH Scholl, N Imin, MA Djordjevic, DM Bird. 2013. Solution NMR studies of the plant peptide hormone CEP inform function.  FEBS Letts, in press doi: 10.1016/j.febslet.2013.10.033

JL Tarigo, EH Scholl, DM Bird, SK Nordone, CC Brown LA Cohn, GA Dean, MG Levy, DL Doolan, A Trieu, PL Felgner, A Vigil, AJ Birkenheuer. 2013. A novel candidate vaccine for cytauxzoonosis inferred from comparative apicomplexan genomics. PLoS One.

DM Bird,  PM DiGennaro. 2013. The complex armory of plant-parasitic nematodes. Chapter 3 in: Parasitic Nematodes, 2nd edition: Molecular Biology, Biochemistry and Immunology, MW Kennedy and W Harnett (Eds), CABI Publishing, Wallingford, UK.

VP Thomas, SL Fudali, JE Schaff, Q Liu, EH Scholl, CH Opperman, DM Bird, VM Williamson. 2012. A sequence-anchored linkage map of the plant-parasitic nematode Meloidogyne hapla reveals exceptionally high genome-wide recombination. G3: GENES| GENOMES| GENETICS, 2: 815-824.



Five Highly-Cited Publications

Lohar DP, Schaff JE, Laskey JG, Kieber, JJ, Bilyeu KD and DM Bird. 2004. Cytokinins play opposite roles in lateral root formation, and nematode and rhizobial symbioses. Plant J., 38: 203-214.

Contrary to what was known about function of the ubiquitous hormone cytokinin, I showed that down regulation of cellular cytokinin is required for lateral root initiation and subsequent cell division.

Opperman CH, Bird DM, Williamson VM. Rohksar DS, Burke M, Cohn J, Cromer J, Diener S, Gajan J, Graham S, Houfek TD, Q Li, Mitros T, Schaff JE, Schaffer R, Scholl E, Sosinski BR, Thomas VP and E Windham. 2008. Sequence and genetic map of Meloidogyne hapla: A compact nematode genome for plant parasitism. Proc. Natl. Acad. Sci. (USA), 105: 14802-14807.

Our complete genome sequence establishes this genetically-tractable parasitic nematode as the reference model to understand plant-parasitism. At 56Mb, this also is the most compact metazoan genome obtained to date.

McCarter JP, Mitreva MD, Martin J, Dante M, Wylie, T, Rao U, Pape D, Bowers Y, Theising B, Murphy C, Kloek AP, Chiapelli B, Clifton SW, Bird DM and R Waterston. 2003. Analysis and functional classification of transcripts from the root-knot nematode Meloidogyne incognita. Genome Biol., 4: R26.1-R26.19.

The first report of genome-scale analysis of a plant-parasitic nematode. This project defined more than 35,000 distinct genes from 14 nematode species and underpinned obtaining the whole genome sequence.

Scholl EH, Thorne JL, McCarter JP and DM Bird. 2003. Horizontally transferred genes in plant-parasitic nematodes: A high-throughput genomic approach. Genome Biol., 4: R39.1-R39.12.

Developed computational tools and confirmed the hypothesis that nematodes acquired genes from bacteria via horizontal gene transfer. This work remains the most definitive evidence for any bacteria-to-animal HGT.

Weerasinghe RR, Bird DM and NS Allen. 2005. Root-knot nematodes and bacterial Nod factors elicit common signal transduction events in Lotus japonicusroot hair cells. Proc. Natl. Acad. Sci. (USA),102: 3147–3152.

Genetics and cell biology reveal Nem Factor as the first signaling molecule inferred for a plant-parasitic nematode and which defines the primary interaction between host and pathogen.



Publication Summary


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